Description

2-(2,6-Dioxopiperidin-3-Yl)-1-Oxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant importance in modern drug discovery and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the field of targeted protein degradation. It is primarily sought after by research institutions, pharmaceutical companies, and CDMOs engaged in the development of next-generation small molecule drugs and PROTACs (Proteolysis Targeting Chimeras).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex active pharmaceutical ingredients (APIs) and investigational new drugs.
• PROTAC Development: Serves as a core component for constructing cereblon E3 ligase-binding ligands, which are essential for designing bifunctional protein degraders.
• Oncology Research: Used in the research and development of novel anti-cancer compounds targeting specific protein pathways.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization processes to improve drug efficacy and selectivity.
• Bioconjugation: The carboxylic acid moiety allows for further chemical modification and conjugation, useful in creating antibody-drug conjugates (ADCs) or other targeted delivery systems.
• Chemical Biology Probes: Utilized to develop molecular probes for studying protein function and cellular degradation mechanisms.

Basic Information

Product Name	2-(2,6-Dioxopiperidin-3-Yl)-1-Oxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid
CAS No.	2171780-01-9
Molecular Formula	C14H12N2O5
Molecular Weight	288.26 g/mol
Synonyms	5-Carboxy Thalidomide; 5-Carboxythalidomide; 1-Oxo-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-5-carboxylic acid; 2-(2,6-Dioxo-3-piperidyl)-1-oxo-2,3-dihydro-1H-isoindole-5-carboxylic acid; 5-Carboxy-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Thalidomide-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2-(2,6-Dioxopiperidin-3-Yl)-1-Oxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All batches are subjected to comprehensive analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.