Description

Mal-Peg5-Amine Tfa Salt is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group for thiol conjugation and a primary amine group for further functionalization, presented as its trifluoroacetate salt. This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise, site-specific cross-linking of biomolecules. It is primarily utilized by researchers and manufacturers in the fields of biopharmaceuticals, antibody-drug conjugate (ADC) development, and diagnostic reagent formulation to create stable, well-defined conjugates with improved pharmacokinetic properties.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• PEGylation of Peptides and Proteins: Used to introduce PEG chains onto cysteine-containing biomolecules via the maleimide-thiol reaction, enhancing solubility and stability.
• Surface Functionalization: Enables the modification of nanoparticles, biosensors, and solid supports with amine-reactive groups for subsequent biomolecule immobilization.
• Diagnostic Probe Synthesis: Facilitates the creation of fluorescent or radioactive probes for imaging and diagnostic assays through conjugation to targeting ligands.
• Cross-linking Reagent: Acts as a versatile spacer for cross-linking two different molecules, one containing a thiol and the other an amine-reactive group.
• Polymer Therapeutics: A fundamental component in the synthesis of advanced polymer-drug conjugates designed for targeted drug delivery.

Basic Information

Product Name	Mal-Peg5-Amine Tfa Salt
CAS No.	2170654-73-4
Molecular Formula	C26H45F3N4O11
Molecular Weight	646.65 g/mol
Synonyms	Maleimide-PEG5-Amine TFA Salt; 3-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)propanamide trifluoroacetate; 1-[3-[2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethylcarbamoyl]propyl]pyrrole-2,5-dione trifluoroacetate; MAL-PEG5-NH2.TFA; Amine-PEG5-Maleimide TFA Salt; mPEG5-MAL Amine TFA Salt; N-(3-Maleimidopropyl)-3,6,9,12-tetraoxapentadecan-1-amine TFA Salt
EINECS	Contact for details

Quality Control

Every batch of Mal-Peg5-Amine Tfa Salt is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with the standards required for research and pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.