Description

trans-Cyclobutane-1,3-Dicarboxylic Acid Mono-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a rigid cyclobutane scaffold with differentiated carboxylic acid functionality. This compound matters as a versatile and critical building block for medicinal chemists, enabling the synthesis of novel, conformationally constrained active pharmaceutical ingredients (APIs) with potential for improved metabolic stability and target selectivity. It is primarily needed by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for constructing complex molecules in drug discovery programs targeting CNS disorders, oncology, and anti-infectives.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a structurally rigid linker component to connect E3 ligase ligands with target protein ligands, enhancing degradation efficiency.
• Peptidomimetic Chemistry: Used to introduce conformational restraint into peptide backbones, improving bioavailability and receptor binding affinity.
• Agrochemical Synthesis: Intermediate for creating novel herbicides or fungicides with the cyclobutane core offering unique spatial properties.
• Material Science Monomer: Potential monomer for synthesizing specialized polyesters or polyamides with tailored thermal and mechanical properties.
• Asymmetric Catalysis Ligand Precursor: The chiral, bifunctional structure can be elaborated into novel ligands for transition metal catalysis.

Basic Information

Product Name	trans-Cyclobutane-1,3-Dicarboxylic Acid Mono-tert-Butyl Ester
CAS No.	2166836-11-7
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	(1R,3S)-Cyclobutane-1,3-dicarboxylic acid 1-tert-butyl ester; (1S,3R)-Cyclobutane-1,3-dicarboxylic acid 3-tert-butyl ester; trans-1-(tert-Butoxycarbonyl)-3-carboxycyclobutane; trans-3-(tert-Butoxycarbonyl)cyclobutane-1-carboxylic Acid; Mono-tert-butyl trans-cyclobutane-1,3-dicarboxylate; trans-1,3-Cyclobutanedicarboxylic Acid Mono-tert-Butyl Ester; (1R,3S)-1-(tert-Butoxycarbonyl)cyclobutane-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our trans-Cyclobutane-1,3-Dicarboxylic Acid Mono-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if frequent access is required.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.