Description

Thalidomide-Nh-Peg1-Nh-Boc CAS NO 2154342-17-1 is a high-purity, synthetic pharmaceutical intermediate designed for advanced drug discovery and development. This compound is critical for researchers and manufacturers requiring precise, reliable building blocks for the synthesis of novel therapeutic agents. It is primarily utilized in the pharmaceutical and biotechnology sectors for the creation of targeted small-molecule drugs and antibody-drug conjugates (ADCs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel small-molecule drug candidates, particularly for oncology and immunology research.
• Proteolysis-Targeting Chimera (PROTAC) Development: Used in the construction of heterobifunctional molecules designed to degrade specific disease-causing proteins.
• Antibody-Drug Conjugate (ADC) Linker-Payload Synthesis: Serves as a component in the creation of specialized linkers or payloads for targeted cancer therapies.
• Chemical Biology & Proteomics: Employed as a tool compound for studying protein-protein interactions and cellular signaling pathways.
• Peptide & Protein Modification: Facilitates the site-specific conjugation or functionalization of peptides and proteins for therapeutic or diagnostic purposes.
• Preclinical & Clinical Research: Supplied to CROs (Contract Research Organizations) and academic institutions for investigative studies and early-stage drug development.

Basic Information

Product Name	Thalidomide-Nh-Peg1-Nh-Boc
CAS No.	2154342-17-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Boc-2-(2-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)ethoxy)ethyl)carbamic acid; tert-Butyl N-[2-[2-[[2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl]amino]ethoxy]ethyl]carbamate; Thalidomide-PEG1-NH-Boc; Boc-NH-PEG1-Thalidomide; PROTAC Linker intermediate; ADC linker component
EINECS	Contact for details

Quality Control

Our Thalidomide-Nh-Peg1-Nh-Boc is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.