Description

5-(4-Cyclopropylphenyl)-1H-Pyrrole-2-Carboxylicacid is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrrole-carboxylic acid scaffold substituted with a cyclopropylphenyl group. This compound is of significant value in medicinal chemistry for the research and development of novel small-molecule therapeutics, particularly targeting enzymes and receptors where this specific molecular architecture is required. It is primarily sought after by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the synthesis of innovative drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Protease/Enzyme Inhibitor Development: Serves as a core scaffold for designing potential inhibitors due to its carboxylic acid functionality and aromatic system.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and novel heterocyclic chemistry studies.

Basic Information

Item	Detail
Product Name	5-(4-Cyclopropylphenyl)-1H-Pyrrole-2-Carboxylicacid
CAS No.	2138546-95-7
Molecular Formula	C14H13NO2
Molecular Weight	227.26 g/mol
Synonyms	5-(4-Cyclopropylphenyl)-1H-pyrrole-2-carboxylic acid; 2-Carboxy-5-(4-cyclopropylphenyl)pyrrole; 1H-Pyrrole-2-carboxylic acid, 5-(4-cyclopropylphenyl)-; 5-(4-Cyclopropylphenyl)-2-pyrrolecarboxylic acid; 2138546-95-7; 5-(p-Cyclopropylphenyl)-1H-pyrrole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 5-(4-Cyclopropylphenyl)-1H-Pyrrole-2-Carboxylicacid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions for API synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.