Description

1-(2-Bromoethyl)-4,4-Difluoropiperidine Hydrobromide is a high-purity, advanced pharmaceutical intermediate and building block. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry research and development. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with specific fluorine-containing motifs.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the 4,4-difluoropiperidine moiety.
• Agrochemical Synthesis: Intermediate in the development of new generation pesticides and herbicides containing fluorine atoms for enhanced efficacy.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological systems and enzyme functions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	1-(2-Bromoethyl)-4,4-Difluoropiperidine Hydrobromide
CAS No.	2138280-09-6
Molecular Formula	C7H12Br2F2N
Molecular Weight	308.99 g/mol
Synonyms	4,4-Difluoro-1-(2-bromoethyl)piperidine hydrobromide; 1-(2-Bromoethyl)-4,4-difluoropiperidine HBr; 4,4-Difluoropiperidine, 1-(2-bromoethyl)-, hydrobromide; (2-Bromoethyl)-4,4-difluoropiperidinium bromide; 4,4-Difluoro-1-(2-bromoethyl)piperidinium bromide
EINECS	Contact for details

Quality Control

Our 1-(2-Bromoethyl)-4,4-Difluoropiperidine Hydrobromide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting cGMP (current Good Manufacturing Practice) compliance for use in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.