Description

2-Oxabicyclo[2.1.1]hexane-4-methanol, 1-methyl- is a specialized bicyclic oxetane derivative, a high-value synthetic intermediate prized for its unique strained ring structure and functional group versatility. This compound matters for enabling advanced synthetic routes in pharmaceutical and materials chemistry, offering a rigid scaffold that can impart desirable properties to final products. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced polymer industries seeking to innovate with novel molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) or anti-infective therapies.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides, fungicides, or insecticides, where its oxetane core can enhance metabolic stability and bioavailability.
• Advanced Material Monomer: Acts as a precursor for high-performance polymers, coatings, or resins, where the incorporation of the bicyclic structure can improve thermal stability, rigidity, and optical properties.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands or organocatalysts for asymmetric synthesis, leveraging its three-dimensional geometry.
• Chemical Biology Probe: Utilized as a scaffold for developing molecular probes to study enzyme function or protein-protein interactions in biological research.
• Cross-Coupling Reactions: Functions as a specialized substrate in transition metal-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create complex, functionalized molecules.

Basic Information

Product Name	2-Oxabicyclo[2.1.1]hexane-4-methanol, 1-methyl-
CAS No.	2138162-49-7
Molecular Formula	C7H12O2
Molecular Weight	128.17 g/mol
Synonyms	1-Methyl-2-oxabicyclo[2.1.1]hexane-4-methanol; 4-(Hydroxymethyl)-1-methyl-2-oxabicyclo[2.1.1]hexane; 1-Methyl-4-(hydroxymethyl)-2-oxabicyclo[2.1.1]hexane; Bicyclic oxetane methanol derivative; Methyl-oxetane bicyclic alcohol; (2-Oxabicyclo[2.1.1]hex-4-yl)methanol, 1-methyl-; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our 2-Oxabicyclo[2.1.1]hexane-4-methanol, 1-methyl- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided and available upon request. We support development and cGMP manufacturing needs with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0% (by GC)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.