Description

Methanesulfonato (Di-tert-Butyl) Methylphosphino (2′-Amino-1,1′-Biphenyl-2-Yl) Palladium(II) is a highly specialized, air-stable palladium catalyst designed for demanding cross-coupling reactions. Its value lies in the unique combination of the bulky, electron-rich phosphine ligand and the methanesulfonate counterion, which enhances solubility and catalytic activity. This compound is essential for researchers and process chemists in the pharmaceutical and advanced materials sectors, where it enables efficient synthesis of complex organic molecules, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions in API development.
• Advanced Material Research: Used in the polymerization and functionalization of organic electronic materials, such as OLEDs and conductive polymers.
• Agrochemical Production: Facilitates the construction of complex heterocyclic compounds found in modern crop protection agents.
• Academic & Industrial R&D: A preferred catalyst for method development and scaling up novel C-N and C-C bond-forming reactions.
• Fine Chemical Manufacturing: Enables the production of high-value, structurally complex specialty chemicals with high selectivity.

Basic Information

Product Name	Methanesulfonato (Di-tert-Butyl) Methylphosphino (2′-Amino-1,1′-Biphenyl-2-Yl) Palladium(II)
CAS No.	2128748-50-3
Molecular Formula	C28H42NOPPdS
Molecular Weight	602.09 g/mol
Synonyms	Buchwald Palladium Precatalyst G4; Methanesulfonato(2'-amino-1,1'-biphenyl-2-yl)palladium(II) Di-tert-butylmethylphosphine Complex; Pd-G4; t-BuBrettPhos Pd G4 Methanesulfonate; (2'-Amino-1,1'-biphenyl-2-yl)palladium(II) methanesulfonate di-tert-butylmethylphosphine complex; Palladium, [2-(2-amino-1,1'-biphenyl)]methanesulfonato-C,N][(1,1-dimethylethyl)[(1,1-dimethylethyl)phosphinous-κP]methyl]-; BrettPhos Pd G4 MsOH
EINECS	Contact for details

Quality Control

Our production of Methanesulfonato (Di-tert-Butyl) Methylphosphino (2′-Amino-1,1′-Biphenyl-2-Yl) Palladium(II) adheres to stringent quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by advanced analytical techniques, including NMR and HPLC, to verify identity, purity, and ligand integrity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (Pd content)	≥ 17.5%
Purity (HPLC)	≥ 98.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.