Description

n-Mal-n-Bis(Peg4-Amine) Tfa Salt is a specialized, high-purity chemical intermediate featuring a maleimide (Mal) core symmetrically functionalized with two tetraethylene glycol (PEG4) amine arms, presented as its trifluoroacetate (TFA) salt. This compound is engineered for precision bioconjugation, offering a controlled and stable reactive handle for linking biomolecules under mild aqueous conditions. It is an essential building block for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science, where reliable and site-specific modification of proteins, peptides, and other functional polymers is required.

Application

• Bioconjugation Reagent: Primary use for site-specific labeling and crosslinking of proteins, antibodies, and peptides via thiol-maleimide chemistry.
• ADC (Antibody-Drug Conjugate) Linker Precursor: Serves as a key intermediate in the synthesis of cleavable or non-cleavable PEGylated linkers for targeted cancer therapies.
• PEGylation Agent: Used to introduce hydrophilic polyethylene glycol (PEG) spacers onto drug molecules or surfaces to enhance solubility, stability, and circulation time.
• Surface Functionalization: Modification of nanoparticles, biosensors, and diagnostic assay substrates to create bioactive interfaces.
• Polymer Chemistry: Building block for synthesizing functionalized, water-soluble polymers and hydrogels with tailored properties.
• Research & Development: Critical tool in academic and industrial R&D for exploring new drug delivery systems and biomaterial constructs.

Basic Information

Product Name	n-Mal-n-Bis(Peg4-Amine) Tfa Salt
CAS No.	2128735-22-6
Molecular Formula	C27H46F3N3O13
Molecular Weight	677.67 g/mol
Synonyms	1,1'-(Methylenebis(oxy))bis(ethane-2,1-diyl) bis(2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl) carbamate maleimide TFA salt; Maleimide-PEG4-amine TFA salt (bis-functional); Bis(PEG4-amino) maleimide trifluoroacetate; n-Maleimidobutyryl-PEG4-amine TFA salt (symmetrical); Bifunctional Maleimide-PEG4-NH2.TFA; 2,2'-(2,2'-(2,2'-(2,2'-(Maleyl-imino)bis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl))bis(oxy))bis(N-(2-aminoethyl)acetamide) trifluoroacetate; MB-PEG4-NH2 TFA Salt
EINECS	Contact for details

Quality Control

Our n-Mal-n-Bis(Peg4-Amine) Tfa Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.