Description

(3-Amino-Cyclobutyl)Acetic Acid Methyl Ester Hydrochloride is a high-purity, pharmaceutically relevant building block used in the synthesis of novel active pharmaceutical ingredients (APIs). This compound is critical for medicinal chemistry research and development, particularly in constructing constrained, three-dimensional molecular scaffolds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on developing next-generation therapeutics, including central nervous system (CNS) and oncology drugs.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel drug candidates, especially those requiring a rigid, functionalized cyclobutane ring system.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and improve pharmacokinetic properties.
• Peptidomimetic Synthesis: Serves as a constrained amino acid analog for creating conformationally restricted peptides with enhanced metabolic stability and receptor selectivity.
• Library Synthesis for High-Throughput Screening: Employed in the generation of diverse compound libraries for biological screening against novel targets.
• Process Chemistry Development: Used in scaling up synthetic routes for clinical trial material (CTM) and commercial API manufacturing under GMP conditions.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	(3-Amino-Cyclobutyl)Acetic Acid Methyl Ester Hydrochloride
CAS No.	2126163-26-4
Molecular Formula	C7H14ClNO2
Molecular Weight	179.65 g/mol
Synonyms	Methyl (3-aminocyclobutyl)acetate hydrochloride; (3-Aminocyclobutyl)acetic acid methyl ester HCl; 1-(Methoxycarbonylmethyl)cyclobutane-3-amine hydrochloride; 3-(Methoxycarbonylmethyl)cyclobutanamine hydrochloride; Methyl 2-(3-aminocyclobutyl)acetate hydrochloride; 2-(3-Aminocyclobutyl)acetic acid methyl ester hydrochloride; Cyclobutanamine, 3-(2-methoxy-2-oxoethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (3-Amino-Cyclobutyl)Acetic Acid Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent determination, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and conformance to agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.