Description

n-(Boc-Peg4)-Nh-Peg4-T-Butyl Ester is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a tert-butyl ester group and a Boc-protected amine. This compound is a critical building block in the synthesis of complex bioconjugates, enabling precise control over linker length, solubility, and functional group presentation. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing advanced drug delivery systems, antibody-drug conjugates (ADCs), and diagnostic probes.

Application

• Bioconjugation Linker: Serves as a versatile spacer and linker for attaching drugs, dyes, or targeting ligands to antibodies, proteins, or nanoparticles.
• Antibody-Drug Conjugate (ADC) Development: A key intermediate for constructing cleavable or non-cleavable linkers in ADC payload synthesis, enhancing therapeutic index.
• Proteolysis-Targeting Chimera (PROTAC) Synthesis: Used to create the flexible PEG-based linker connecting the E3 ligase ligand and the target protein ligand.
• Peptide and Protein Modification: Enables site-specific PEGylation to improve pharmacokinetic properties, stability, and solubility of therapeutic peptides.
• Diagnostic Agent Formulation: Employed in the development of contrast agents and imaging probes for MRI, fluorescence, and other diagnostic modalities.
• Polymer Chemistry: Acts as a functional monomer or macroinitiator for synthesizing advanced, stimuli-responsive block copolymers.
• Material Surface Functionalization: Used to create hydrophilic, non-fouling coatings on medical devices and biosensor surfaces.

Basic Information

Product Name	n-(Boc-Peg4)-Nh-Peg4-T-Butyl Ester
CAS No.	2112737-17-2
Molecular Formula	C33H65NO15
Molecular Weight	715.86 g/mol
Synonyms	1-Boc-1,4,7,10,13-pentaoxa-16-azacyclooctadecan-16-acetic acid tert-butyl ester; 2,5,8,11,14-Pentaoxa-17-azanonadecan-19-oic acid, 17-[(1,1-dimethylethoxy)carbonyl]-, 1,1-dimethylethyl ester; Boc-NH-PEG4-CH2CH2COOH-t-butyl ester; tert-Butyl 2-(2-(2-(2-(2-(2-(2-(2-(tert-butoxy)-2-oxoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethylamino)acetate; Boc-PEG4-NH-PEG4-t-butyl ester; Heterobifunctional PEG, Boc-PEG4-NH-PEG4-COOtBu; 16-[(tert-Butoxycarbonyl)amino]-4,7,10,13-tetraoxa-16-azahexadecan-1-oic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our n-(Boc-Peg4)-Nh-Peg4-T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, supporting its use in research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.