Description

(S)-4-Carboxyphenylglycine Hydrochloride is a high-purity chiral amino acid derivative, specifically the hydrochloride salt of the (S)-enantiomer. This compound is a critical chiral building block and intermediate in the synthesis of advanced pharmaceuticals and bioactive molecules. It is essential for research and production in the pharmaceutical industry, particularly for developing active pharmaceutical ingredients (APIs) with specific stereochemical requirements.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Peptide Synthesis: Used as a protected amino acid derivative for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Biochemical Research: Employed as a standard or reagent in enzymatic studies and for investigating amino acid transport and metabolism.
• Agrochemical Synthesis: Potential intermediate in the development of chiral herbicides or plant growth regulators.
• Diagnostic Agent Precursor: Can be utilized in the development of contrast agents or molecular probes for imaging.

Basic Information

Product Name	(S)-4-Carboxyphenylglycine Hydrochloride
CAS No.	2109874-13-5
Molecular Formula	C9H10ClNO4
Molecular Weight	231.63 g/mol
Synonyms	(S)-2-Amino-2-(4-carboxyphenyl)acetic acid hydrochloride; (S)-4-Carboxyphenylglycine HCl; (S)-α-Amino-4-carboxybenzenacetic acid hydrochloride; L-4-Carboxyphenylglycine hydrochloride; (S)-Amino(4-carboxyphenyl)acetic acid hydrochloride; 4-CPGA hydrochloride (S-form); (S)-2-(4-Carboxyphenyl)glycine hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-4-Carboxyphenylglycine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) specifying identity, purity (typically ≥98%), enantiomeric excess (ee), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.