Description

3-(Difluoromethyl)Bicyclo[1.1.1]Pentan-1-Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique strained bicyclic scaffold. This compound is valued for its role in medicinal chemistry, particularly in the development of novel small-molecule therapeutics where its structure can impart favorable metabolic stability and physicochemical properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring a rigid, three-dimensional core structure.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space and improve drug-like properties.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of bifunctional molecules for targeted protein degradation.
• CNS Drug Discovery: Its scaffold is of significant interest for developing compounds that can cross the blood-brain barrier for treating neurological conditions.
• Agrochemical Research: May be investigated as an intermediate for novel active ingredients in crop protection products.
• Chemical Biology Probes: Used to create tool compounds for studying biological pathways and target validation.

Basic Information

Item	Details
Product Name	3-(Difluoromethyl)Bicyclo[1.1.1]Pentan-1-Amine Hydrochloride
CAS No.	2108549-79-5
Molecular Formula	C7H12ClF2N
Molecular Weight	183.63 g/mol
Synonyms	3-(Difluoromethyl)bicyclo[1.1.1]pentan-1-amine hydrochloride; 3-(Difluoromethyl)-1-bicyclo[1.1.1]pentanyl-amine hydrochloride; 1-Amino-3-(difluoromethyl)bicyclo[1.1.1]pentane hydrochloride; [1.1.1]Propellane, 3-(difluoromethyl)-1-amino-, hydrochloride; Bicyclo[1.1.1]pentan-1-amine, 3-(difluoromethyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Bicyclo[1.1.1]Pentan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and relevant industry guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.