Description

trans-4-Fluoro-3-Methoxypyrrolidine Hydrochloride (Wx601068) is a high-purity, fluorinated pyrrolidine derivative offered as a hydrochloride salt, serving as a critical chiral building block in advanced organic synthesis. This compound is valued for its ability to introduce both fluorine and methoxy functional groups into complex molecular architectures, significantly influencing the pharmacokinetic and metabolic properties of target molecules. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, especially for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated pesticides and herbicides where the pyrrolidine core enhances biological activity.
• Ligand and Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics & Bioactive Molecules: Incorporated into peptide backbones and other bioactive compounds to improve metabolic stability and membrane permeability.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Material Science Research: Acts as a monomer or functionalizing agent in the development of specialty polymers and advanced materials.

Basic Information

Product Name	trans-4-Fluoro-3-Methoxypyrrolidine Hydrochloride (Wx601068)
CAS No.	2108511-81-3
Molecular Formula	C5H11FNO • HCl
Molecular Weight	155.60 (Free base) / 192.02 (HCl salt)
Synonyms	(3R,4S)-4-Fluoro-3-methoxypyrrolidine hydrochloride; (3S,4R)-4-Fluoro-3-methoxypyrrolidine hydrochloride; trans-4-Fluoro-3-methoxy-pyrrolidine HCl; 4-Fluoro-3-methoxypyrrolidine HCl (trans); WX-601068; 2108511-81-3; 4-Fluoro-3-methoxy-1-azabicyclo[3.1.0]hexane hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates. Each batch is characterized and controlled using advanced analytical techniques including HPLC, GC, NMR, and MS to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, providing full transparency on specifications such as assay, enantiomeric excess, and impurity profiles. We adhere to a cGMP-compliant quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.