Description

tert-Butyl 5-Chloro-2-Oxospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate CAS NO 2103402-31-7 is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indoline-piperidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel bioactive molecules. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery of new therapeutic agents targeting central nervous system (CNS) disorders and other disease areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those with spirocyclic architectures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new chemical entities.
• CNS Drug Discovery: The structural motif suggests applications in developing therapeutics for neurological and psychiatric conditions.
• Proteolysis Targeting Chimera (PROTAC) Development: Can serve as a component in the design of bifunctional molecules for targeted protein degradation.
• Kinase Inhibitor Synthesis: Potential use as a core scaffold for creating selective kinase inhibitors.
• Contract Manufacturing: Supplied to CDMOs for scale-up and cGMP production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	tert-Butyl 5-Chloro-2-Oxospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate
CAS No.	2103402-31-7
Molecular Formula	C17H21ClN2O3
Molecular Weight	336.81 g/mol
Synonyms	1'-Boc-5-chloro-2-oxospiro[indoline-3,4'-piperidine]; tert-Butyl 5-chloro-2-oxo-1,2-dihydrospiro[indole-3,4'-piperidine]-1'-carboxylate; 5-Chloro-1,2-dihydrospiro[indole-3,4'-piperidine]-2-one 1'-tert-butyl carboxylate; Boc-5-chloro-2-oxospiro[indoline-3,4'-piperidine]; Spiro[indoline-3,4'-piperidine]-2-one, 5-chloro-, 1'-(1,1-dimethylethyl) ester; 5-Chloro-2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; CAS 2103402-31-7
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Chloro-2-Oxospiro[Indoline-3,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with the standards expected for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This product is moisture-sensitive (hygroscopic) and should be handled under inert atmosphere when appropriate to ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.