Description

5-tert-Butyl 6-Methyl (6S)-4-Oxo-5-Azaspiro[2.4]Heptane-5,6-Dicarboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic structure. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of next-generation small molecule drugs, where its stereochemical purity and structural integrity are paramount for successful clinical outcomes.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex APIs targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved efficacy and safety profiles.
• Process Chemistry Development: Serves as a critical starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) guidelines.
• Asymmetric Synthesis: Exploits its defined (6S) stereochemistry for the construction of other enantiomerically pure compounds.
• Contract Research & Manufacturing (CRAM): Supplied to organizations specializing in custom synthesis and development services for the global pharmaceutical industry.

Basic Information

Product Name	5-tert-Butyl 6-Methyl (6S)-4-Oxo-5-Azaspiro[2.4]Heptane-5,6-Dicarboxylate
CAS No.	2102412-64-4
Molecular Formula	C14H21NO5
Molecular Weight	283.32 g/mol
Synonyms	(6S)-5-(tert-Butoxycarbonyl)-6-(methoxycarbonyl)-4-oxo-5-azaspiro[2.4]heptane; (6S)-5-tert-Butyl 6-Methyl 4-Oxo-5-azaspiro[2.4]heptane-5,6-dicarboxylate; 5-Azaspiro[2.4]heptane-5,6-dicarboxylic acid, 4-oxo-, 5-(1,1-dimethylethyl) 6-methyl ester, (6S)-; (6S)-Boc-Protected Azaspiroheptane Ester; Spirocyclic Proline Derivative Intermediate
EINECS	Contact for details

Quality Control

Every batch of 5-tert-Butyl 6-Methyl (6S)-4-Oxo-5-Azaspiro[2.4]Heptane-5,6-Dicarboxylate is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure compliance with exacting purity and stereochemical specifications required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥97% by HPLC), chiral excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Any individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.