Description

tert-Butyl 3,3-Difluoro-1,6-Diazaspiro[3.3]Heptane-1-Carboxylate Hydrochloride is a high-value, advanced pharmaceutical intermediate featuring a unique difluorinated spirocyclic scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel bioactive molecules. It serves as a key building block for pharmaceutical companies and research institutions focused on developing next-generation therapeutics, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry R&D: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads in bifunctional degrader molecules.
• Kinase Inhibitor Synthesis: Incorporated into molecules designed to modulate kinase activity for oncology and inflammatory disease applications.
• Chemical Biology Probes: Utilized to create tool compounds for investigating biological targets and mechanisms within cellular systems.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents with enhanced properties.

Basic Information

Product Name	tert-Butyl 3,3-Difluoro-1,6-Diazaspiro[3.3]Heptane-1-Carboxylate Hydrochloride
CAS No.	2102412-20-2
Molecular Formula	C11H17ClF2N2O2
Molecular Weight	282.71 g/mol
Synonyms	1,6-Diazaspiro[3.3]heptane-1-carboxylic acid, 3,3-difluoro-, 1,1-dimethylethyl ester, hydrochloride; 1-(tert-Butoxycarbonyl)-3,3-difluoro-1,6-diazaspiro[3.3]heptane hydrochloride; 3,3-Difluoro-1,6-diazaspiro[3.3]heptane-1-carboxylic acid tert-butyl ester hydrochloride; tert-Butyl 3,3-difluoro-1,6-diazaspiro[3.3]heptane-1-carboxylate HCl; Boc-3,3-difluoro-1,6-diazaspiro[3.3]heptane hydrochloride; 3,3-Difluoro-1-Boc-1,6-diazaspiro[3.3]heptane hydrochloride
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,3-Difluoro-1,6-Diazaspiro[3.3]Heptane-1-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the material under an inert atmosphere or in a desiccator for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.