Description

(3R)-6-Fluoro-2,3-Dihydrobenzo[B]Furan-3-Ylamine Hydrochloride CAS NO 2102408-57-9 is a high-purity chiral amine hydrochloride salt, serving as a critical building block in modern pharmaceutical synthesis. Its value lies in providing a defined stereocenter essential for developing active pharmaceutical ingredients (APIs) with targeted biological activity. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly in central nervous system (CNS) and oncology research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting neurological disorders.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and process chemistry stages for constructing complex molecular architectures.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in reactions requiring high enantiomeric purity.
• Medicinal Chemistry Research: A valuable scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-up: Serves as a starting material for developing robust, scalable synthetic routes to potential APIs.
• Reference Standard: Used as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(3R)-6-Fluoro-2,3-Dihydrobenzo[B]Furan-3-Ylamine Hydrochloride
CAS No.	2102408-57-9
Molecular Formula	C8H9ClFNO
Molecular Weight	189.61 g/mol
Synonyms	(3R)-6-Fluoro-2,3-dihydro-1-benzofuran-3-amine hydrochloride; (R)-6-Fluoro-2,3-dihydrobenzofuran-3-amine HCl; 6-Fluoro-(3R)-2,3-dihydrobenzo[b]furan-3-ylamine hydrochloride; (3R)-6-Fluoro-2,3-dihydrobenzofuran-3-amine hydrochloride; (R)-6-Fluoro-2,3-dihydrobenzo[b]furan-3-amine hydrochloride; 2102408-57-9; (R)-6-Fluoro-3-amino-2,3-dihydrobenzofuran hydrochloride
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing specific results for chiral purity (enantiomeric excess), chemical purity (HPLC), and other critical parameters are available upon request. Our quality systems support development under cGMP guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.