Description

8-Quinolinecarbonitrile, 5-[(3R,5S)-3-Amino-5-(Trifluoromethyl)-1-Piperidinyl]- is a high-purity, advanced pharmaceutical intermediate featuring a complex quinoline-piperidine hybrid structure. This compound is of significant commercial interest due to its role as a key building block in the synthesis of novel, potent drug candidates, particularly in therapeutic areas requiring targeted molecular scaffolds. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new chemical entities, especially for applications in medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) for investigational drugs.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in structure-activity relationship (SAR) studies and lead optimization.
• Process Development & Scale-up: Employed in the development and optimization of robust, scalable synthetic routes for potential commercial manufacturing.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the pharmaceutical industry.
• Targeted Drug Discovery: Its specific stereochemistry and functional groups make it valuable for programs targeting receptors or enzymes where such motifs are privileged.

Basic Information

Item	Details
Product Name	8-Quinolinecarbonitrile, 5-[(3R,5S)-3-Amino-5-(Trifluoromethyl)-1-Piperidinyl]-
CAS No.	2101938-42-3
Molecular Formula	C16H15F3N4
Molecular Weight	320.32 g/mol
Synonyms	5-[(3R,5S)-3-Amino-5-(trifluoromethyl)piperidin-1-yl]quinoline-8-carbonitrile; (3R,5S)-1-(8-Cyanoquinolin-5-yl)-5-(trifluoromethyl)piperidin-3-amine; 5-[(3R,5S)-3-Amino-5-(trifluoromethyl)-1-piperidinyl]-8-quinolinecarbonitrile; 8-Cyano-5-[(3R,5S)-3-amino-5-(trifluoromethyl)piperidin-1-yl]quinoline; CAS 2101938-42-3
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing, including chiral purity verification, to ensure compliance with the stringent requirements of pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity (typically by HPLC), chiral assay, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.