Description

Aminooxy-PEG4-t-butyl ester is a heterobifunctional polyethylene glycol (PEG) linker featuring a protected aminooxy group and a tert-butyl ester terminus. This compound is engineered to facilitate the site-specific conjugation of biomolecules, such as antibodies, peptides, and oligonucleotides, through oxime ligation. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, ADC (Antibody-Drug Conjugate) development, and advanced material science. The CAS number for this compound is 2100306-82-7.

Application

• Bioconjugation Reagent: Used for the site-specific modification of proteins, antibodies, and peptides via oxime bond formation with ketone or aldehyde groups.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component for attaching cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapies.
• PEGylation: Acts as a functionalized PEG spacer to improve the solubility, stability, and pharmacokinetic properties of therapeutic biomolecules.
• Surface Functionalization: Utilized to modify nanoparticles, biosensors, and diagnostic assay surfaces with reactive aminooxy groups for further coupling.
• Cross-linking Agent: Enables the creation of hydrogels, polymer networks, and biomaterial scaffolds for tissue engineering and drug delivery systems.
• Chemical Biology Probes: Facilitates the synthesis of activity-based probes and imaging agents for studying biological processes.

Basic Information

Item	Detail
Product Name	Aminooxy-PEG4-t-butyl ester
CAS No.	2100306-82-7
Molecular Formula	C19H37NO8
Molecular Weight	407.5 g/mol
Synonyms	t-Butyl 17-amino-4,7,10,13-tetraoxa-16-azaheptadecanoate; Aminooxy-PEG4-OtBu; Boc-NH-PEG4-CH2CH2-COOtBu (Note: Common misnomer, this is the Boc-protected amine variant); 2-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethoxy]ethyl 3-(tert-butoxy)-3-oxopropanoate; Aminooxy functionalized PEG4 t-butyl ester; Heterobifunctional PEG linker, Aminooxy/OtBu; 4-Arm PEG-Aminooxy, t-butyl ester (Note: Common related structure)
EINECS	Contact for details

Quality Control

Our Aminooxy-PEG4-t-butyl ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical development. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and moisture content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.