Description

Bromo-Peg3-Ch2Co2Tbu is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive bromo group and a protected carboxylic acid (t-butyl ester). This compound is a critical building block in bioconjugation and pharmaceutical development, enabling the precise attachment of molecules for targeted drug delivery and diagnostic applications. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, proteomics, and ADC (Antibody-Drug Conjugate) development.

Application

• Bioconjugation Reagent: Used to link peptides, proteins, or antibodies with other functional molecules like drugs, dyes, or polymers.
• ADC (Antibody-Drug Conjugate) Linker: Serves as a key component in the synthesis of cleavable or non-cleavable linkers for targeted cancer therapies.
• PEGylation Agent: Employed to modify biomolecules with polyethylene glycol chains to improve solubility, stability, and pharmacokinetic properties.
• Crosslinking and Surface Modification: Facilitates the functionalization of surfaces, nanoparticles, and materials for biosensing and diagnostic applications.
• Proteomics Research: Acts as a tool for labeling and studying protein-protein interactions and cellular pathways.
• Polymer and Dendrimer Synthesis: Used as a monomer or branching unit in the construction of advanced polymeric architectures.

Basic Information

Product Name	Bromo-Peg3-Ch2Co2Tbu
CAS No.	2100306-71-4
Molecular Formula	C15H29BrO6
Molecular Weight	385.30 g/mol
Synonyms	2,5,8,11-Tetraoxatetradecan-14-oic acid, 14-bromo-3,6,9-trioxa-12-azatetradecan-1-oic acid 1,1-dimethylethyl ester (related structure); 1-Bromo-3,6,9-trioxaundecan-11-yl t-butyl acetate; Bromo-PEG3-t-butyl ester; t-Butyl 2-(2-(2-(2-bromoethoxy)ethoxy)ethoxy)acetate; Bromo-triethylene glycol-t-butyl ester; PEG3-Br-tBu ester; Heterobifunctional PEG linker Br-PEG3-COOtBu
EINECS	Contact for details

Quality Control

Our Bromo-Peg3-Ch2Co2Tbu is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant cGMP and ISO 9001 standards for critical raw materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.