Description

Amino-Peg2-T-Boc-Hydrazide is a heterobifunctional polyethylene glycol (PEG) linker featuring a Boc-protected hydrazide group and a primary amine. This compound is engineered to facilitate the controlled conjugation of biomolecules, offering a hydrophilic spacer that enhances solubility and reduces immunogenicity. It is a critical reagent for researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and peptide synthesis who require precise and stable crosslinking strategies.

Application

• Bioconjugation and Crosslinking: Used as a versatile linker for coupling carboxylic acids or carbonyl-containing molecules (via the hydrazide group) to amines (via the primary amine), ideal for creating protein-protein or protein-small molecule conjugates.
• Antibody-Drug Conjugate (ADC) Development: Serves as a key building block for constructing cleavable or non-cleavable linkers, connecting cytotoxic payloads to monoclonal antibodies while improving pharmacokinetic properties.
• Peptide and Protein Modification: Enables site-specific PEGylation to enhance the stability, solubility, and circulating half-life of therapeutic peptides and proteins.
• Diagnostic Reagent Synthesis: Employed in the preparation of labeled probes and contrast agents for imaging and diagnostic assays.
• Polymer Chemistry: Acts as a functional initiator or monomer for synthesizing specialized PEG-based copolymers with reactive end-groups.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and other material surfaces with amine-reactive groups for subsequent biomolecule immobilization.

Basic Information

Product Name	Amino-Peg2-T-Boc-Hydrazide
CAS No.	2100306-60-1
Molecular Formula	C15H31N3O6
Molecular Weight	349.43 g/mol
Synonyms	Boc-NH-PEG2-hydrazide; 2-[2-(2-{[(tert-Butoxy)carbonyl]amino}ethoxy)ethoxy]acetohydrazide; 1-Boc-amino-3,6-dioxa-8-octanehydrazide; tert-Butyl N-[2-[2-(2-hydrazinyl-2-oxoethoxy)ethoxy]ethyl]carbamate; Amino-PEG2-Boc-hydrazide; Boc-Amino-PEG2-hydrazide; Heterobifunctional PEG linker, Boc-hydrazide/amine
EINECS	Contact for details

Quality Control

Our Amino-Peg2-T-Boc-Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, to ensure compliance with exacting standards for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.