Description

Verubecestat Trifluoroacetate is a high-purity trifluoroacetate salt form of the investigational BACE1 inhibitor, Verubecestat. This compound is a critical intermediate and reference standard in pharmaceutical research and development, particularly for studies targeting Alzheimer's disease. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors requiring precise, well-characterized materials for preclinical and analytical applications.

Application

• Pharmaceutical Reference Standard: Serves as a primary standard for analytical method development, validation, and quality control (QC/QA) of active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a key tool compound in in vitro and in vivo studies to investigate BACE1 enzyme inhibition and its role in amyloid-beta peptide production.
• Preclinical Development: Employed in pharmacokinetic (PK), pharmacodynamic (PD), and toxicology studies during the drug discovery pipeline for neurological disorders.
• Process Chemistry & Scale-up: Acts as an intermediate or starting material for the synthesis of other derivatives or for process optimization in API manufacturing.
• Academic Research: Utilized in university and institutional labs for fundamental neuroscience research related to Alzheimer's disease pathways.

Basic Information

Product Name	Verubecestat Trifluoroacetate
CAS No.	2095432-65-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Verubecestat TFA Salt; MK-8931 Trifluoroacetate; (S)-2-((S)-2-(3,5-Difluorophenyl)-2-hydroxyacetamido)-N-((S)-1-(4-fluorophenyl)-3,4-dihydro-1H-isoquinoline-3-carboxamido)-3-methylbutanamide Trifluoroacetate; BACE Inhibitor Verubecestat Trifluoroacetate; β-Secretase 1 Inhibitor Verubecestat Trifluoroacetate; MK 8931 Trifluoroacetate
EINECS	Contact for details

Quality Control

Our Verubecestat Trifluoroacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.