Description

trans-4-Ethynylcyclohexanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique cyclohexylamine scaffold bearing an ethynyl functional group. This compound is of significant value in modern medicinal chemistry for its role as a versatile building block in the synthesis of complex molecules, particularly for targeted drug discovery programs. It is primarily utilized by research institutions and pharmaceutical companies engaged in developing novel therapeutics, including kinase inhibitors and other small-molecule active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel small-molecule drug candidates, especially in oncology and CNS therapeutic areas.
• Kinase Inhibitor Synthesis: Serves as a crucial building block for constructing potent and selective kinase inhibitors due to its ability to act as a linker or a functional group handle.
• Chemical Biology Probes: Used in the development of chemical probes for studying enzyme function and biological pathways, leveraging the reactivity of the alkyne group for click chemistry applications.
• Peptidomimetic Research: Incorporated into peptide backbones to create rigid, conformationally constrained analogs for enhanced stability and binding affinity.
• Material Science Research: Potential monomer or cross-linking agent in the development of specialized polymers with unique thermal or mechanical properties.
• Academic & Industrial R&D: Employed in exploratory synthetic chemistry for method development and the creation of novel chemical libraries for high-throughput screening.

Basic Information

Product Name	trans-4-Ethynylcyclohexanamine Hydrochloride
CAS No.	2095396-33-9
Molecular Formula	C8H14ClN
Molecular Weight	159.66 g/mol
Synonyms	trans-4-Ethynylcyclohexylamine hydrochloride; (1r,4r)-4-Ethynylcyclohexan-1-amine hydrochloride; 4-Ethynylcyclohexanamine hydrochloride, trans-; 4-Ethynylcyclohexylamine HCl; 2095396-33-9; trans-4-Ethynyl-1-cyclohexanamine hydrochloride; (trans)-4-Ethynylcyclohexanamine HCl; 4-Ethynylcyclohexanamine HCl (trans isomer)
EINECS	Contact for details

Quality Control

Our trans-4-Ethynylcyclohexanamine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.