Description

Thalidomide-Nh-C6-Nh2 Tfa is a high-purity, functionalized thalidomide derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block and linker molecule in the synthesis of Proteolysis Targeting Chimeras (PROTACs) and other targeted protein degradation therapeutics. It is essential for medicinal chemists and research institutions focused on oncology, immunology, and neurodegenerative disease pathways. The precise chemical modification enables the creation of novel bifunctional molecules for investigating new therapeutic modalities.

Application

• PROTAC Linker Chemistry: A key component for constructing heterobifunctional degraders that link an E3 ubiquitin ligase binder to a protein-of-interest (POI) ligand.
• Targeted Protein Degradation (TPD) Research: Used in the development of molecular glues and degrader platforms for preclinical drug discovery.
• Chemical Biology Probes: Enables the study of protein function and cellular signaling pathways through targeted degradation.
• Oncology Drug Development: Facilitates the creation of novel therapeutics aimed at degrading oncogenic proteins considered "undruggable" by conventional inhibitors.
• Bioconjugation: The amine-terminated alkyl chain allows for further conjugation to various molecules, peptides, or solid supports.
• Academic & Institutional Research: Supports fundamental research in ubiquitin-proteasome system (UPS) biology and novel therapeutic mechanisms.

Basic Information

Product Name	Thalidomide-Nh-C6-Nh2 Tfa
CAS No.	2093386-51-5
Molecular Formula	C23H22F3N3O7S
Molecular Weight	541.50 g/mol
Synonyms	2-(2,6-Dioxopiperidin-3-yl)-4-((6-((2,2,2-trifluoroacetamido)hexyl)amino)isoindoline-1,3-dione; Thalidomide-C6-NH2 TFA; Thalidomide-6-aminohexyl-TFA; TFA-Thalidomide-C6-NH2; (S)-Thalidomide-C6-NH2 TFA; PROTAC Linker Thalidomide derivative; E3 Ligase Ligand Linker; Cereblon Ligand Conjugate
EINECS	Contact for details

Quality Control

Our Thalidomide-Nh-C6-Nh2 Tfa is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines for advanced pharmaceutical intermediates, and specifications can be tailored to meet specific project requirements. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.