Description

2-((1R,4R)-4-(tert-Butoxycarbonyl)Cyclohexyl)Ethyl 4-Methylbenzenesulfonate is a high-purity, stereochemically defined synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for constructing complex molecules with defined stereochemistry, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and other therapeutic areas requiring chiral specificity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel drug candidates, particularly for CNS-targeting therapeutics.
• Peptidomimetic & PROTAC Synthesis: Used in the construction of complex scaffolds for proteolysis-targeting chimeras (PROTACs) and peptide-mimicking molecules.
• Asymmetric Synthesis: Serves as a precursor for introducing the (1R,4R)-cyclohexyl moiety with high enantiomeric purity into target molecules.
• Chemical Biology Probes: Employed in the development of labeled or tagged chemical probes for target identification and validation studies.
• Process Chemistry Development: Used in route scouting and optimization for the scalable production of chiral APIs under Good Manufacturing Practice (GMP) guidelines.
• Academic & Contract Research: A valuable reagent for universities and CROs conducting research in synthetic methodology and medicinal chemistry.

Basic Information

Product Name	2-((1R,4R)-4-(tert-Butoxycarbonyl)Cyclohexyl)Ethyl 4-Methylbenzenesulfonate
CAS No.	2093293-77-5
Molecular Formula	C21H32O5S
Molecular Weight	396.54 g/mol
Synonyms	(1R,4R)-4-[(2-[(4-Methylphenyl)sulfonyl]oxy)ethyl]cyclohexane-1-carboxylic acid tert-butyl ester; (1R,4R)-tert-Butyl 4-(2-((tosyloxy)ethyl))cyclohexane-1-carboxylate; (1R,4R)-Boc-4-(2-hydroxyethyl)cyclohexyl tosylate (precursor name); (1R,4R)-4-(2-Tosyloxyethyl)cyclohexylcarboxylic acid tert-butyl ester; (1R,4R)-Tosylate of Boc-protected cyclohexylethanol; BOC-(1R,4R)-Cyclohexylethyl Tosylate; (1R,4R)-Boc-CHEt-OTs
EINECS	Contact for details

Quality Control

Our 2-((1R,4R)-4-(tert-Butoxycarbonyl)Cyclohexyl)Ethyl 4-Methylbenzenesulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. We employ advanced analytical techniques including HPLC, chiral HPLC, GC, and NMR to verify identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality commitment aligns with the standards expected for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.