Description

1-(1-Bromo-2,2,2-Trifluoroethyl)-4-Nitrobenzene is a high-value, multi-functional organic building block characterized by its unique combination of bromo, trifluoromethyl, and nitro substituents on an aromatic ring. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring trifluoromethyl groups for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the nitro and bromo groups serve as handles for further functionalization.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form complex biaryl structures.
• Fluorine Chemistry: Essential for introducing the trifluoroethyl moiety into target molecules, a common strategy in medicinal chemistry to fine-tune lipophilicity and potency.
• Nitro Reduction & Further Derivatization: The nitro group can be selectively reduced to an amine, opening pathways to a wide array of aniline derivatives and heterocycles.

Basic Information

Product Name	1-(1-Bromo-2,2,2-Trifluoroethyl)-4-Nitrobenzene
CAS No.	2091158-96-0
Molecular Formula	C8H5BrF3NO2
Molecular Weight	284.03 g/mol
Synonyms	4-Nitro-α-(bromomethyl)benzotrifluoride; 1-Bromo-2,2,2-trifluoro-1-(4-nitrophenyl)ethane; (1-Bromo-2,2,2-trifluoroethyl)-4-nitrobenzene; p-Nitro-(α-bromotrifluoroethyl)benzene; α-Bromo-α,α,α-trifluoro-4-nitrotoluene; 4-Nitrobenzyl Bromide, α,α,α-trifluoro-; 1-(4-Nitrophenyl)-2,2,2-trifluoroethyl Bromide
EINECS	Contact for details

Quality Control

Our 1-(1-Bromo-2,2,2-Trifluoroethyl)-4-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.