Description

7-Bromo-4-Chloro-8-Fluoroquinazoline is a high-purity, multi-halogenated quinazoline derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a versatile intermediate for constructing complex molecules with tailored biological and physical properties. This compound is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of kinase inhibitors, anticancer agents, and other small-molecule drug candidates targeting various disease pathways.
• Agrochemical Research: Used to develop new herbicides, fungicides, and pesticides by exploiting the bioactivity of the quinazoline core.
• Material Science: Serves as a building block for creating organic semiconductors, liquid crystals, and fluorescent dyes due to its electron-deficient aromatic system.
• Chemical Biology: Employed as a molecular probe or a tag in medicinal chemistry for structure-activity relationship (SAR) studies.
• Custom Synthesis: Provides a functionalized scaffold for contract research organizations (CROs) and CDMOs to perform further cross-coupling and substitution reactions.

Basic Information

Product Name	7-Bromo-4-Chloro-8-Fluoroquinazoline
CAS No.	2089651-77-2
Molecular Formula	C8H3BrClFN2
Molecular Weight	261.48 g/mol
Synonyms	8-Fluoro-7-bromo-4-chloroquinazoline; 4-Chloro-7-bromo-8-fluoroquinazoline; Quinazoline, 7-bromo-4-chloro-8-fluoro-; 2089651-77-2; 7-Bromo-4-chloro-8-fluoro-quinazoline
EINECS	Contact for details

Quality Control

Our 7-Bromo-4-Chloro-8-Fluoroquinazoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. The container should be kept tightly sealed to protect this light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.