Description

6-(Trifluoromethyl)Quinoline-8-Carboxylic Acid is a high-value, multifunctional heterocyclic building block prized for its unique structural features. Its core value lies in the combination of the quinoline scaffold with a carboxylic acid group and a strategically positioned electron-withdrawing trifluoromethyl group, enabling precise molecular design and modification. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, where it serves as a critical intermediate in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and central nervous system (CNS) agents.
• Agrochemical Research: Used in the synthesis of advanced crop protection agents, leveraging the trifluoromethyl group to enhance biological activity, metabolic stability, and lipophilicity.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chelating ligands and organocatalysts in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science: Employed in the synthesis of functional organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers, where the quinoline core contributes to electron-transport properties.
• Chemical Biology Probe: Utilized as a building block for fluorescent tags and molecular probes to study biological processes and enzyme functions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis services catering to R&D and pilot-scale production needs.

Basic Information

Product Name	6-(Trifluoromethyl)Quinoline-8-Carboxylic Acid
CAS No.	2089649-11-4
Molecular Formula	C11H6F3NO2
Molecular Weight	241.17 g/mol
Synonyms	8-Quinolinecarboxylic acid, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)-8-quinolinecarboxylic acid; 6-Trifluoromethylquinoline-8-carboxylic acid; Quinoline-8-carboxylic acid, 6-(trifluoromethyl)-; 2089649-11-4; 6-CF3-Quinoline-8-carboxylic acid
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)Quinoline-8-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.