Description

4-(3,3-Difluoropyrrolidin-1-Yl)Piperidine 2Hcl is a high-purity, advanced pharmaceutical intermediate and building block of significant importance in modern drug discovery. This compound matters because it provides a critical, functionalized piperidine-pyrrolidine scaffold essential for synthesizing bioactive molecules, particularly in the development of central nervous system (CNS) and oncology therapeutics. Pharmaceutical R&D teams and fine chemical manufacturers need this material for its role in creating potent, selective small-molecule drug candidates targeting a range of diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for CNS disorders and oncology.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• API (Active Pharmaceutical Ingredient) Development: Serves as a precursor in the multi-step synthesis of complex active ingredients.
• Biochemical Tool Compound: Employed in pharmacological research to study receptor interactions and enzyme inhibition.
• Contract Manufacturing & Development (CDMO): Supplied to CDMOs for the scale-up and cGMP production of clinical trial materials.
• Library Synthesis: Used for creating diverse chemical libraries for drug discovery programs.

Basic Information

Product Name	4-(3,3-Difluoropyrrolidin-1-Yl)Piperidine 2Hcl
CAS No.	2089315-11-5
Molecular Formula	C9H17Cl2F2N2
Molecular Weight	271.15 g/mol
Synonyms	4-(3,3-Difluoropyrrolidin-1-yl)piperidine dihydrochloride; 1-(Piperidin-4-yl)-3,3-difluoropyrrolidine dihydrochloride; 4-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride (1:2); 4-(3,3-Difluoropyrrolidin-1-Yl)Piperidine 2HCl; 2089315-11-5; 4-(3,3-Difluoropyrrolidin-1-Yl)Piperidine Dihydrochloride
EINECS	Contact for details

Quality Control

Our 4-(3,3-Difluoropyrrolidin-1-Yl)Piperidine 2Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and development. Certificates of Analysis (COA) with full analytical data are provided for every shipment, ensuring traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.