Description

tert-Butyl 6-Bromo-2-oxospiro[indoline-3,3'-pyrrolidine]-1-carboxylate (Wx106483) is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic indoline-pyrrolidine scaffold. This compound is of significant value for its role as a key building block in the synthesis of novel bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical companies and contract research organizations (CROs) engaged in the discovery and process development of new therapeutic agents, especially those targeting central nervous system (CNS) disorders and other complex disease pathways.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug candidates, particularly those with spirocyclic architectures.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential component for constructing linkers or warheads in targeted protein degradation technologies.
• Chemical Biology Probes: Utilized in the development of molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Employed in the development and optimization of robust, scalable synthetic routes for active pharmaceutical ingredient (API) manufacturing.
• Academic Research: Used in university and institutional labs for methodological studies in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 6-Bromo-2-oxospiro[indoline-3,3'-pyrrolidine]-1-carboxylate (Wx106483)
CAS No.	2089310-17-6
Molecular Formula	C17H21BrN2O3
Molecular Weight	381.27 g/mol
Synonyms	1-Boc-6-bromo-2-oxospiro[indoline-3,3'-pyrrolidine]; tert-Butyl 6-bromo-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-1-carboxylate; 6-Bromo-1-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,3'-pyrrolidine]; Wx106483; 2089310-17-6; Spiro[indoline-3,3'-pyrrolidine]-2-one, 6-bromo-1-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Bromo-2-oxospiro[indoline-3,3'-pyrrolidine]-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your R&D and regulatory documentation needs. We adhere to cGMP principles where applicable to ensure batch-to-batch consistency for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability. Keep the container sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.