Description

cis-2-Amino-Cyclobutanol Hydrochloride is a high-purity, pharmaceutically relevant chiral building block and synthetic intermediate. Its value lies in its constrained cyclobutane ring structure, which is increasingly sought after in medicinal chemistry for creating novel bioactive molecules with improved metabolic stability and potency. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients, particularly for applications in drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, infectious diseases, and metabolic conditions.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and scaffold hopping to explore new chemical space and optimize lead compounds.
• Agrochemical Synthesis: Serves as a precursor for developing advanced herbicides, fungicides, and insecticides with unique modes of action.
• Ligand and Catalyst Development: Utilized in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Peptidomimetics and Bioisosteres: The amino-cyclobutanol moiety is incorporated into peptide analogs to enhance stability, bioavailability, and receptor selectivity.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic synthesis and chemical biology studies.

Basic Information

Product Name	cis-2-Amino-Cyclobutanol Hydrochloride
CAS No.	2070860-49-8
Molecular Formula	C4H10ClNO
Molecular Weight	123.58 g/mol
Synonyms	2-Aminocyclobutanol hydrochloride, cis-; cis-2-Aminocyclobutyl alcohol hydrochloride; (1r,2s)-2-Aminocyclobutanol hydrochloride; (1s,2r)-2-Aminocyclobutanol hydrochloride; Cyclobutanol, 2-amino-, hydrochloride, cis-; 2-Amino-1-cyclobutanol hydrochloride; cis-2-Amino-1-cyclobutanol HCl
EINECS	Contact for details

Quality Control

Our cis-2-Amino-Cyclobutanol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profile is supplied with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.