Description

Aminooxy-Peg3-Nh-Boc is a heterobifunctional polyethylene glycol (PEG) crosslinker featuring a protected aminooxy group and a Boc-protected amine. This compound is essential for creating stable, site-specific conjugations in bioconjugation chemistry, particularly for linking carbonyl-containing molecules to amine-reactive surfaces or biomolecules. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing antibody-drug conjugates (ADCs), peptide therapeutics, and advanced diagnostic assays.

Application

• Bioconjugation Reagent: For the site-specific conjugation of aldehydes or ketones (e.g., from oxidized glycans or periodate-treated antibodies) to amine-containing targets.
• Antibody-Drug Conjugate (ADC) Development: Used as a linker to attach cytotoxic payloads to monoclonal antibodies via oxime bond formation, offering improved stability and controlled release profiles.
• PEGylation Chemistry: Serves as a functionalized PEG spacer to modify peptides, proteins, or surfaces, enhancing solubility, stability, and pharmacokinetic properties.
• Surface Functionalization: Immobilization of biomolecules onto solid supports (e.g., biosensors, microarray slides, nanoparticles) through amine-reactive chemistry.
• Proteomics Research: Tool for chemical labeling, crosslinking, or affinity purification of proteins and peptides.
• Polymer Chemistry: Building block for synthesizing functionalized polymers and hydrogels with tailored reactive handles.

Basic Information

Item	Details
Product Name	Aminooxy-Peg3-Nh-Boc
CAS No.	2062663-65-2
Molecular Formula	C18H36N2O8
Molecular Weight	408.5 g/mol
Synonyms	Boc-NH-PEG3-Aminooxy; 1-Amino-3,6,9-trioxa-12-azatetradecan-14-oic acid, 13-[(1,1-dimethylethoxy)carbonyl]-12-(aminooxy)-, 1,1-dimethylethyl ester; t-Butyl (2-(2-(2-(aminooxy)ethoxy)ethoxy)ethyl)carbamate; Aminooxy-PEG3-amine-Boc; Boc-protected Aminooxy-PEG3-amine; O-(2-Aminoethyl)-O'-(2-(Boc-amino)ethyl)triethylene glycol; Boc-N-amido-PEG3-aminooxy
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg3-Nh-Boc is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and pharmaceutical development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.