Description

Isoquinoline, 1-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]- is a specialized chiral isoquinoline derivative featuring an oxazoline moiety, serving as a high-value synthetic intermediate. This compound is critical for enabling asymmetric synthesis and the construction of complex nitrogen-containing heterocycles. It is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and oncology.
• Ligand Precursor: Used in the preparation of chiral oxazoline-based ligands for asymmetric catalysis, enabling enantioselective transformations in fine chemical manufacturing.
• Agrochemical Research: Intermediate in the development of new pesticides and herbicides with specific stereochemical requirements for enhanced activity.
• Academic & Institutional Research: Employed in synthetic organic chemistry research to explore new methodologies and construct complex molecular architectures.
• Material Science: Potential precursor for functionalized polymers or advanced materials requiring specific nitrogen-based heterocyclic structures.

Basic Information

Item	Details
Product Name	Isoquinoline, 1-[(4S)-4,5-Dihydro-4-Phenyl-2-Oxazolyl]-
CAS No.	2058236-53-4
Molecular Formula	C18H16N2O
Molecular Weight	276.34 g/mol
Synonyms	(S)-4-Phenyl-4,5-dihydro-2-(isoquinolin-1-yl)oxazole; 1-[(4S)-4,5-Dihydro-4-phenyl-1,3-oxazol-2-yl]isoquinoline; (S)-1-(4-Phenyl-4,5-dihydrooxazol-2-yl)isoquinoline; Chiral Isoquinoline-Oxazoline Ligand Precursor; (S)-PQO (abbreviation); 1-[(S)-4,5-Dihydro-4-phenyl-2-oxazolyl]isoquinoline; (S)-1-(4-Phenyl-2-oxazolinyl)isoquinoline
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized using advanced analytical techniques to confirm identity, purity, and enantiomeric excess. Certificates of Analysis (COA) are available upon request, detailing specifications such as assay, chiral purity, and impurity profiles. We adhere to a cGMP-compliant quality management system for research-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.