Description

(1S)-1-Cyclobutyl-2,2,2-Trifluoroethan-1-Amine Hydrochloride is a high-purity chiral amine hydrochloride salt, serving as a critical building block in advanced organic synthesis. Its value lies in the combination of a cyclobutyl ring and a trifluoroethylamine motif, which are key structural elements for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and exploring structure-activity relationships.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and metabolic disease targets.
• Agrochemical Synthesis: Used in the design and synthesis of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Methodology Development: Serves as a model substrate in academic and industrial research for developing new asymmetric synthesis routes and catalytic transformations.
• Ligand and Catalyst Preparation: Utilized for the synthesis of specialized chiral ligands and organocatalysts used in enantioselective reactions.
• Peptidomimetics & Bioisosteres: The cyclobutyl and trifluoroethylamine groups are valuable bioisosteric replacements in peptide mimetics and drug design to improve potency and pharmacokinetic profiles.
• Material Science Research: Investigated as a precursor for specialty monomers or additives in the development of advanced polymers with unique properties.

Basic Information

Product Name	(1S)-1-Cyclobutyl-2,2,2-Trifluoroethan-1-Amine Hydrochloride
CAS No.	2055849-25-5
Molecular Formula	C6H11F3N • HCl
Molecular Weight	193.61 g/mol (Free base)
Synonyms	(1S)-1-Cyclobutyl-2,2,2-trifluoroethanamine hydrochloride; (S)-1-Cyclobutyl-2,2,2-trifluoroethylamine HCl; (S)-α-(Trifluoromethyl)cyclobutanemethylamine hydrochloride; (S)-1-Cyclobutyl-2,2,2-trifluoroethan-1-amine HCl; (S)-1-Cyclobutyl-2,2,2-trifluoroethanamine HCl salt; (S)-CF3-Cyclobutylmethylamine hydrochloride; (S)-Trifluoroethylcyclobutylamine hydrochloride
EINECS	Contact for details

Quality Control

Our (1S)-1-Cyclobutyl-2,2,2-Trifluoroethan-1-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing chiral purity, assay, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.