Description

Methyl 1-(Benzenesulfonyl)-3-Methyl-1H-Indole-2-Carboxylate CAS NO 2055840-89-4 is a high-purity, advanced pharmaceutical intermediate featuring a functionalized indole core. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of novel drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used extensively in research and development (R&D) laboratories for structure-activity relationship (SAR) studies and lead optimization.
• Synthesis of Kinase Inhibitors: Acts as a core scaffold for constructing potent and selective kinase inhibitors, a major class of oncology and anti-inflammatory drugs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of APIs (Active Pharmaceutical Ingredients) under cGMP conditions.
• Chemical Biology Probes: Utilized in the development of chemical probes to study specific biological processes and protein functions.
• Academic Research: Employed in university and institutional labs for pioneering synthetic methodology development and heterocyclic chemistry studies.

Basic Information

Product Name	Methyl 1-(Benzenesulfonyl)-3-Methyl-1H-Indole-2-Carboxylate
CAS No.	2055840-89-4
Molecular Formula	C18H17NO4S
Molecular Weight	343.40 g/mol
Synonyms	1-(Phenylsulfonyl)-3-methyl-1H-indole-2-carboxylic acid methyl ester; Methyl 3-methyl-1-(phenylsulfonyl)-1H-indole-2-carboxylate; 1-Benzenesulfonyl-3-methyl-1H-indole-2-carboxylic acid methyl ester; 3-Methyl-1-tosyl-1H-indole-2-carboxylic acid methyl ester (common misnomer for benzenesulfonyl); 1H-Indole-2-carboxylic acid, 1-(benzenesulfonyl)-3-methyl-, methyl ester; N-Benzenesulfonyl-3-methylindole-2-carboxylate methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 1-(Benzenesulfonyl)-3-Methyl-1H-Indole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.