Description

(2,2-Difluorocyclobutyl)Methanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique difluorocyclobutyl scaffold. This compound is of significant commercial interest for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting metabolic and central nervous system disorders.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the difluorocyclobutyl group can enhance biological activity and environmental stability.
• Material Science: Serves as a precursor for specialty polymers and advanced materials with tailored thermal and chemical resistance properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization programs to introduce fluorine atoms for improved metabolic stability and membrane permeability.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and scale-up services for the life sciences industry.

Basic Information

Product Name	(2,2-Difluorocyclobutyl)Methanamine Hydrochloride
CAS No.	2055839-95-5
Molecular Formula	C6H12ClF2N
Molecular Weight	171.62 g/mol
Synonyms	1-(2,2-Difluorocyclobutyl)methanamine hydrochloride; (2,2-Difluorocyclobutyl)methylamine hydrochloride; 2,2-Difluorocyclobutanemethanamine hydrochloride; 1-(Aminomethyl)-2,2-difluorocyclobutane hydrochloride; 2,2-Difluoro-1-(aminomethyl)cyclobutane hydrochloride; 1-(2,2-Difluorocyclobutyl)-N-methylamine hydrochloride; 2,2-Difluorocyclobutylmethylamine HCl
EINECS	Contact for details

Quality Control

Our (2,2-Difluorocyclobutyl)Methanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications and supporting regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.