Description

2-Oxa-8-Azaspiro[4.5]Decan-4-Amine, 3-Methyl-, Hydrochloride (1:2), (3S,4S)- is a high-purity, stereochemically defined spirocyclic amine hydrochloride salt, serving as a critical pharmaceutical intermediate and chiral building block for advanced organic synthesis. Its value lies in the precise three-dimensional structure, which is essential for developing active pharmaceutical ingredients (APIs) with specific biological activity. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical and biotechnology sectors engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel therapeutic agents, particularly for central nervous system (CNS) and metabolic disorder targets.
• Drug Discovery & Medicinal Chemistry: Used as a constrained scaffold to explore structure-activity relationships (SAR) and improve the pharmacokinetic properties of lead compounds.
• Process Chemistry & API Development: Employed in the scale-up and optimization of synthetic routes for candidate drugs during clinical development.
• Asymmetric Synthesis: Serves as a chiral auxiliary or precursor for constructing complex molecules with high enantiomeric purity.
• Chemical Biology & Proteomics: Can be utilized as a molecular probe or linker for studying biological systems and protein interactions.
• Academic & Industrial R&D: A valuable reagent for methodological research in organic synthesis and the development of new catalytic transformations.

Basic Information

Product Name	2-Oxa-8-Azaspiro[4.5]Decan-4-Amine, 3-Methyl-, Hydrochloride (1:2), (3S,4S)-
CAS No.	2055761-19-6
Molecular Formula	C9H18N2O • 2HCl
Molecular Weight	267.18 g/mol
Synonyms	(3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine dihydrochloride; (3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine hydrochloride (2:1); 2-Oxa-8-azaspiro[4.5]decan-4-amine, 3-methyl-, hydrochloride (1:2), (3S,4S)-; (3S,4S)-3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine dihydrochloride salt; Spirocyclic amine dihydrochloride; (3S,4S)- enantiomer of 3-Methyl-2-oxa-8-azaspiro[4.5]decan-4-amine 2HCl
EINECS	Contact for details

Quality Control

Our 2-Oxa-8-Azaspiro[4.5]Decan-4-Amine, 3-Methyl-, Hydrochloride (1:2), (3S,4S)- is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (3S,4S)-
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.