Description

Active-Mono-Sulfone-Peg8-Acid CAS NO 2055048-45-6 is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative featuring a terminal sulfone group and a carboxylic acid group, designed for advanced bioconjugation and linker chemistry. This compound is critical for creating stable, cleavable linkages in pharmaceutical development, particularly for antibody-drug conjugates (ADCs) and targeted drug delivery systems. It is essential for R&D scientists and process developers in the biopharmaceutical, diagnostic, and advanced materials sectors who require precise and reliable PEGylation reagents.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a key intermediate for constructing cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: Used to modify proteins, peptides, and nanoparticles to enhance solubility, stability, and circulation half-life.
• Bioconjugation Chemistry: Enables site-specific coupling of molecules via its reactive sulfone and carboxylic acid functionalities.
• Polymer Chemistry: Acts as a functional monomer or cross-linking agent for synthesizing advanced hydrogels and functional polymers.
• Diagnostic Probe Synthesis: Utilized in the development of labeled probes and contrast agents for imaging and detection.
• Surface Functionalization: Applied to modify material surfaces for improved biocompatibility and specific binding properties.

Basic Information

Product Name	Active-Mono-Sulfone-Peg8-Acid
CAS No.	2055048-45-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)oxy)-8-oxooctyl 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-sulfonate; PEG8-Sulfone-NHS ester; NHS-PEG8-Sulfone; Heterobifunctional PEG8 Sulfone NHS Ester; Sulfone-PEG8-acid; 1-(8-((2,5-Dioxopyrrolidin-1-yl)oxy)-8-oxooctyl) 2,5-dioxo-2,5-dihydro-1H-pyrrole-1-sulfonate; mPEG-Sulfone-NHS
EINECS	Contact for details

Quality Control

Our Active-Mono-Sulfone-Peg8-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting full specifications are available upon request. We support development and cGMP manufacturing needs with a commitment to traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.