Description

n-(Amino-Peg3)-n-Bis(Peg3-T-Butyl Ester) Hcl Salt is a high-purity, heterobifunctional polyethylene glycol (PEG) derivative, a critical building block for advanced bioconjugation and linker chemistry. This compound matters because it provides a precisely engineered spacer arm with a primary amine for coupling and protected carboxylic acid termini, enabling controlled, multi-step synthesis of complex molecules. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material science who require reliable, high-quality linkers for creating antibody-drug conjugates (ADCs), peptide therapeutics, and functionalized surfaces.

Application

• Antibody-Drug Conjugate (ADC) Linker Synthesis: Serves as a key intermediate for constructing cleavable or non-cleavable linkers that connect cytotoxic payloads to monoclonal antibodies.
• Peptide and Protein Modification: Used to introduce PEG spacers (PEGylation) to improve pharmacokinetics, solubility, and stability of therapeutic peptides and proteins.
• Biomaterial and Surface Functionalization: Enables the covalent attachment of biomolecules to nanoparticles, diagnostic assay surfaces, and tissue engineering scaffolds.
• Crosslinking Reagent: Acts as a heterobifunctional crosslinker for conjugating molecules containing different reactive groups (e.g., amines to carboxyls).
• Solid-Phase Peptide Synthesis (SPPS): Employed as a building block to incorporate flexible, hydrophilic PEG-based spacers into synthetic peptide chains.
• Dendrimer and Polymer Synthesis: A valuable monomer for constructing branched, multi-functional polymeric architectures with controlled geometry.
• Diagnostic Probe Development: Facilitates the creation of labeled probes for imaging and detection applications by linking targeting moieties to reporter molecules.

Basic Information

Product Name	n-(Amino-Peg3)-n-Bis(Peg3-T-Butyl Ester) Hcl Salt
CAS No.	2055042-62-9
Molecular Formula	C31H62N2O13 • HCl
Molecular Weight	707.3 g/mol (Free base: 670.8 g/mol)
Synonyms	1-Amino-3,6,9,12,15,18,21-heptaoxatritriacontan-33-oic acid, 33-(1,1-dimethylethyl) ester, hydrochloride; 15-Amino-4,7,10,13-tetraoxapentadecanoic acid, α,α-bis[1,1-dimethylethoxy]carbonyl]-, hydrochloride; Amino-PEG3-acid-(t-Bu ester)2 HCl salt; Heterobifunctional PEG3 linker amine and t-butyl ester HCl salt; N1-(2-Aminoethyl)-N1-bis[2-[2-[2-[2-(1,1-dimethylethoxy)-2-oxoethoxy]ethoxy]ethoxy]ethyl]glycinamide hydrochloride; PEG3-amine-PEG3-(t-Bu ester)2 HCl
EINECS	Contact for details

Quality Control

Every batch of our n-(Amino-Peg3)-n-Bis(Peg3-T-Butyl Ester) Hcl Salt is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure it meets the high standards required for research and pharmaceutical applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or CoA. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.