Description

Nh-(Peg4-T-Butyl Ester)2 CAS NO 2055041-41-1 is a specialized bifunctional PEG derivative featuring two terminal tert-butyl ester-protected carboxylic acid groups linked by a tetraethylene glycol (PEG4) spacer. This compound is a critical intermediate for the synthesis of complex molecules, offering controlled solubility and a defined, flexible linker arm for bioconjugation and materials science applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotech, and advanced materials sectors for developing drug delivery systems, diagnostic probes, and functional polymers.

Application

• Bioconjugation Linker: Serves as a versatile, hydrophilic spacer for attaching targeting ligands, dyes, or drugs to proteins, antibodies, and nanoparticles.
• Protease-Cleavable Linker Precursor: Used in the development of antibody-drug conjugates (ADCs) and prodrugs, where the tert-butyl ester groups can be deprotected to form cleavable peptide linkages.
• Polymer & Dendrimer Synthesis: Acts as a building block for creating functionalized, water-soluble polymers, dendrimers, and hydrogels with tailored properties.
• Surface Functionalization: Employed to modify surfaces (e.g., gold nanoparticles, silica, chips) with carboxylic acid groups for subsequent coupling in biosensor and microarray fabrication.
• Solid-Phase Peptide Synthesis (SPPS): Used as a soluble PEG-based support or as a side-chain modifier to enhance peptide solubility during synthesis.
• Cross-linking Agent: Functions as a homo-bifunctional cross-linker for connecting amine-containing molecules after activation of the carboxylic acid groups.

Basic Information

Item	Details
Product Name	Nh-(Peg4-T-Butyl Ester)2
CAS No.	2055041-41-1
Molecular Formula	C26H50N2O10
Molecular Weight	550.69 g/mol
Synonyms	1,11-Bis(tert-butoxycarbonyl)-4,7,10-trioxa-2-azatridecan-13-oic acid, 2,2'-(Ethylenedioxy)bis(ethyliminodi(ethane-2,1-diyl)) bis(2-methylpropanoate), BOC-NH-PEG4-T-Butyl Ester, Amino-PEG4-t-butyl ester, tert-Butyl 2,2'-(2,2'-(ethane-1,2-diylbis(oxy))bis(ethane-2,1-diyl)bis(azanediyl))diacetate, Bifunctional PEG4 t-butyl ester, NH2-PEG4-COOtBu
EINECS	Contact for details

Quality Control

Our Nh-(Peg4-T-Butyl Ester)2 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and cGMP manufacturing. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.