Description

Aminooxy-Peg8-Methane is a heterobifunctional polyethylene glycol (PEG) linker featuring a reactive aminooxy group at one terminus and a methoxy group at the other. This compound is a critical reagent for site-specific bioconjugation, enabling the stable oxime ligation of biomolecules under mild, aqueous conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostics industries for the development of advanced therapeutics, including antibody-drug conjugates (ADCs), and for modifying peptides, proteins, and surfaces.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of drugs, toxins, or fluorophores to antibodies, proteins, or peptides via oxime bond formation.
• Surface Functionalization: Modification of sensor chips, nanoparticles, or solid supports for biosensor and diagnostic assay development.
• PEGylation Reagent: Introduction of a hydrophilic PEG8 spacer to improve the solubility, stability, and pharmacokinetic properties of therapeutic molecules.
• Crosslinking Agent: For creating stable linkages between carbonyl-containing molecules (e.g., glycoproteins, aldehydes) and other functionalized entities.
• Chemical Biology Probes: Synthesis of activity-based probes or affinity tags for studying protein function and interactions.
• Hydrogel Formation: As a building block in the synthesis of crosslinked polymer networks for controlled release or tissue engineering applications.

Basic Information

Product Name	Aminooxy-Peg8-Methane
CAS No.	2055024-52-5
Molecular Formula	C19H39NO10
Molecular Weight	441.52 g/mol
Synonyms	Aminooxy-PEG8-OMe; Aminooxy-PEG8-methyl ether; Methoxy-PEG8-aminooxy; α-Methoxy-ω-aminooxy-octa(ethylene glycol); O-(2-Aminooxyethyl)-O'-methyl-octaethylene glycol; 2,5,8,11,14,17,20,23-Octaoxapentacosan-25-ol, 24-(aminooxy)-; Aminooxy functionalized PEG; Aminooxy-PEG8-CH3
EINECS	Contact for details

Quality Control

Our Aminooxy-Peg8-Methane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive bioconjugation applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially light-sensitive nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or oil
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Assay	≥ 90% (Aminooxy)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.