Description

Propargyl-Peg3-Sulfone-Peg3-Propargyl is a specialized heterobifunctional crosslinker featuring terminal propargyl groups connected by a sulfone-bridged polyethylene glycol (PEG) spacer. This compound is engineered to enable highly efficient, bioorthogonal conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) click chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the precise construction of complex molecular architectures, including antibody-drug conjugates (ADCs), peptide and protein modifications, and advanced polymer synthesis.

Application

• Antibody-Drug Conjugate (ADC) Development: Serves as a cleavable, hydrophilic linker to connect cytotoxic payloads to monoclonal antibodies, enhancing solubility and pharmacokinetics.
• Peptide and Protein Modification: Enables site-specific labeling, PEGylation, and functionalization of biomolecules for therapeutic and diagnostic applications.
• Polymer and Dendrimer Synthesis: Acts as a key building block for creating functionalized, branched, or cross-linked polymeric materials with tailored properties.
• Bioconjugation and Probe Development: Used to attach fluorescent dyes, affinity tags, or other functional groups to biomolecules for imaging, detection, and assay development.
• Material Surface Functionalization: Facilitates the covalent attachment of bioactive molecules to nanoparticles, biosensors, and other material surfaces.
• Chemical Biology Research: A critical tool for studying protein-protein interactions, cellular pathways, and developing novel chemical probes.

Basic Information

Product Name	Propargyl-Peg3-Sulfone-Peg3-Propargyl
CAS No.	2055024-44-5
Molecular Formula	C20H34O9S
Molecular Weight	450.55 g/mol
Synonyms	1,11-Bis(prop-2-yn-1-yloxy)-3,6,9-trioxa-12-aza-11λ6-thiadodecane 11,11-dioxide; Propargyl-PEG3-sulfone-PEG3-propargyl; Bis(propargyl-PEG3) sulfone; PEG3-Sulfone-PEG3 bis-propargyl linker; Heterobifunctional PEG-sulfone crosslinker; Click chemistry linker, sulfone-PEG3-alkyne; Alkyne-PEG3-Sulfone-PEG3-Alkyne
EINECS	Contact for details

Quality Control

Our Propargyl-Peg3-Sulfone-Peg3-Propargyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, IR), to ensure it meets the high standards required for research and bioconjugation applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay purity, water content, and residual solvents. We support cGMP manufacturing for advanced therapeutic applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool environment. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture absorption. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.