Description

n-Me-D-Ser-Oh·Hcl CAS NO 2044710-40-7 is a high-purity, non-natural amino acid derivative, specifically the hydrochloride salt of N-methyl-D-serine. This compound is a critical chiral building block in modern synthetic organic chemistry and pharmaceutical research. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, enzyme inhibitors, and other bioactive molecules where precise stereochemistry and side-chain modification are essential.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug candidates, particularly in oncology and metabolic disease research.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce N-methylated serine residues, which can enhance metabolic stability and alter conformational properties of peptides.
• Protease Inhibitor Development: Acts as a core structural component in the design of selective inhibitors for serine and other proteases.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and labeled peptides for studying enzyme function and protein-protein interactions.
• Agrochemical Research: Potential use as a building block for developing novel chiral active ingredients with specific biological activity.
• Academic Research: A valuable reagent for methodological studies in asymmetric synthesis and for exploring new reaction pathways involving amino acid derivatives.

Basic Information

Product Name	n-Me-D-Ser-Oh·Hcl
CAS No.	2044710-40-7
Molecular Formula	C4H10ClNO3
Molecular Weight	155.58 g/mol
Synonyms	N-Methyl-D-serine hydrochloride; D-N-Methylserine HCl; (R)-2-Amino-3-hydroxy-N-methylpropanoic acid hydrochloride; (R)-2-(Methylamino)-3-hydroxypropanoic acid hydrochloride; D-Serine, N-methyl-, hydrochloride; Methyl-D-serine hydrochloride; n-Me-D-Ser-OH·HCl; 2044710-40-7
EINECS	Contact for details

Quality Control

Our n-Me-D-Ser-Oh·Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing HPLC purity, chiral excess, and identity confirmation is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.