Description

Dbco-Amine Tfa is a high-purity, functionalized chemical building block designed for advanced bioconjugation and click chemistry applications. Its core value lies in the highly reactive dibenzocyclooctyne (DBCO) group, which enables rapid, catalyst-free, and bioorthogonal ligation with azide-functionalized molecules under mild physiological conditions. This compound is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation, where precise and stable biomolecule labeling is critical.

Application

• Bioconjugation Reagent: For site-specific labeling of antibodies, proteins, peptides, and oligonucleotides with azide-containing probes, drugs, or fluorophores.
• ADC (Antibody-Drug Conjugate) Development: Enables the stable and efficient linkage of cytotoxic payloads to monoclonal antibodies via a cleavable or non-cleavable linker.
• Proteomics & Biomarker Discovery: Used in activity-based protein profiling (ABPP) and other chemical proteomics strategies to tag and identify novel enzyme targets.
• Diagnostic Kit Manufacturing: Critical for developing sensitive lateral flow assays (LFAs), ELISA kits, and other in-vitro diagnostics requiring stable reporter molecule attachment.
• Polymer & Material Science: Functionalization of surfaces, hydrogels, nanoparticles, and polymers for creating bioactive materials and targeted drug delivery systems.
• Cell Imaging & Tracking: Labeling of cell-surface glycans or other targets for real-time fluorescence imaging and flow cytometry.

Basic Information

Product Name	Dbco-Amine Tfa
CAS No.	2007915-94-6
Molecular Formula	C₂₀H₁₆F₃N₃O₃
Molecular Weight	403.35 g/mol
Synonyms	DBCO-NH2 TFA salt; Dibenzocyclooctyne-amine TFA salt; DBCO-Amine Trifluoroacetate; 11-Azido-3,6,9-trioxaundecan-1-amine, DBCO derivative; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-((2-(2-aminoethoxy)ethoxy)ethyl)carbamate TFA; DBCO-PEG3-Amine TFA; Amine-PEG3-DBCO TFA salt
EINECS	Contact for details

Quality Control

Our Dbco-Amine Tfa is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive research and production applications. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.