Description

n-Fmoc-5-Bromo-2-Chloro-L-Phenylalanine is a protected, non-natural amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is a critical building block for the research and development of novel peptide-based pharmaceuticals and biochemical tools. It is primarily utilized by medicinal chemists and research scientists in pharmaceutical R&D, biotechnology, and academic institutions for constructing complex peptides with specific halogenated aromatic side chains.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected amino acid monomer for the automated synthesis of custom peptides.
• Medicinal Chemistry Research: Used in the design and synthesis of peptide drug candidates, particularly those targeting protein-protein interactions where halogen atoms can enhance binding affinity and metabolic stability.
• Chemical Biology Probes: Incorporated into peptides to create labeled or modified probes for studying enzyme mechanisms, receptor binding, and cellular pathways.
• Pharmaceutical Intermediate: Acts as a chiral intermediate in the multi-step synthesis of more complex active pharmaceutical ingredients (APIs).
• Library Synthesis: Employed in combinatorial chemistry to generate diverse peptide libraries for high-throughput screening against biological targets.

Basic Information

Product Name	n-Fmoc-5-Bromo-2-Chloro-L-Phenylalanine
CAS No.	2002401-84-3
Molecular Formula	C24H19BrClNO4
Molecular Weight	524.77 g/mol
Synonyms	Fmoc-5-Br-2-Cl-L-Phe-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-(5-bromo-2-chlorophenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-5-bromo-2-chloro-L-phenylalanine; Fmoc-5-Bromo-2-chloro-L-phenylalanine; N-α-Fmoc-5-Bromo-2-Chloro-L-phenylalanine; 5-Bromo-2-chloro-L-phenylalanine, N-Fmoc derivative; Fmoc-L-Phe(5-Br-2-Cl)-OH
EINECS	Contact for details

Quality Control

Our n-Fmoc-5-Bromo-2-Chloro-L-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the high standards required for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the product should be handled under dry conditions and allowed to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.