Description

2-(3,4-Dimethoxyphenyl)-6-(1-Pyrrolidinyl)-4(3H)-Quinazolinone CAS NO 299897-95-3 is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs) targeting complex therapeutic pathways. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new chemical entities, particularly for central nervous system (CNS) and oncology applications.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of investigational drug candidates, especially kinase inhibitors and receptor modulators.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Used in vitro and in vivo to study specific biological pathways and validate novel drug targets.
• Contract Manufacturing (CMO): Supplied to custom synthesis organizations for the production of clinical trial materials under GMP conditions.
• Academic Research: Employed in university and institutional labs for the development of new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	2-(3,4-Dimethoxyphenyl)-6-(1-Pyrrolidinyl)-4(3H)-Quinazolinone
CAS No.	299897-95-3
Molecular Formula	C20H21N3O3
Molecular Weight	351.40 g/mol
Synonyms	6-(Pyrrolidin-1-yl)-2-(3,4-dimethoxyphenyl)quinazolin-4(3H)-one; 2-(3,4-Dimethoxyphenyl)-6-(pyrrolidin-1-yl)-4(3H)-quinazolinone; 4(3H)-Quinazolinone, 2-(3,4-dimethoxyphenyl)-6-(1-pyrrolidinyl)-; 299897-95-3; UNII-9K3Q8FQ8Q2; 9K3Q8FQ8Q2; BDBM50111273; SCHEMBL155077; AKOS025147324
EINECS	Contact for details

Quality Control

Our 2-(3,4-Dimethoxyphenyl)-6-(1-Pyrrolidinyl)-4(3H)-Quinazolinone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP guidelines. Specifications are tailored to meet the rigorous demands of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers should be kept sealed under an inert atmosphere when not in use to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.