Description

Naphthalene, 2-Fluorodecahydro-, (2R,4Ar,8As)-Rel- (9Ci) is a stereochemically defined fluorinated decahydronaphthalene derivative, serving as a high-value synthetic intermediate and chiral building block in advanced organic synthesis. Its precise stereochemistry and fluorine substitution make it a critical component for developing novel pharmaceuticals and agrochemicals with enhanced biological activity and metabolic stability. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate complex, fluorinated polycyclic frameworks into their target molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorine atom can improve lipophilicity and target binding.
• Chiral Ligand & Catalyst Development: Serves as a sophisticated scaffold for constructing chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique thermal or optical properties.
• Fluorine Chemistry Studies: A valuable reference compound in academic and industrial research focused on the synthesis and reactivity of aliphatic fluorides within polycyclic systems.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fragrance and flavor ingredients requiring specific stereochemistry.

Basic Information

Product Name	Naphthalene, 2-Fluorodecahydro-, (2R,4Ar,8As)-Rel- (9Ci)
CAS No.	298197-83-8
Molecular Formula	C10H17F
Molecular Weight	156.24 g/mol
Synonyms	rel-(2R,4aR,8aS)-2-Fluorodecahydronaphthalene; (2R,4aR,8aS)-2-Fluoro-perhydronaphthalene; 2-Fluorodecahydronaphthalene (rel-(2R,4aR,8aS)-isomer); Fluorinated Decalin Derivative; 2-Fluoro-cis-Decalin (stereospecific); Chiral Fluorodecahydronaphthalene; 298197-83-8; rel-2-Fluorodecahydronaphthalene with (2R,4aR,8aS) configuration
EINECS	Contact for details

Quality Control

Every batch of Naphthalene, 2-Fluorodecahydro-, (2R,4Ar,8As)-Rel- (9Ci) is produced and analyzed under strict quality management protocols. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, which are critical for sensitive synthetic applications. Certificates of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles are available upon request. Our quality systems support compliance with cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases. For long-term storage under an inert atmosphere (nitrogen or argon), please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC or HPLC)	≥ 97.0%
Chiral Purity (Chiral GC/HPLC)	≥ 98.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.