Description

2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylacetamide is a high-value fluorinated acetamide derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a hexafluoroisopropanol (HFIP) moiety, provides exceptional properties for modifying the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorinated group enhances bioavailability and environmental persistence.
• Material Science Precursor: Serves as a monomer or modifier in the creation of specialty polymers and coatings with enhanced chemical resistance and unique surface properties.
• Ligand & Catalyst Development: Employed in organometallic chemistry and catalysis research to construct complex, fluorinated ligands for asymmetric synthesis.
• Life Science Reagents: Utilized in biochemical and proteomic research for labeling and modifying biomolecules to study protein interactions and functions.
• Custom Synthesis & Contract Manufacturing: A pivotal intermediate for custom synthesis houses serving the pharmaceutical and biotechnology industries.

Basic Information

Product Name	2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylacetamide
CAS No.	294196-95-5
Molecular Formula	C12H10ClF6NO2
Molecular Weight	349.66 g/mol
Synonyms	2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-methylacetamide; N-Methyl-2-chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)phenyl]acetamide; 2-Chloro-N-methyl-N-[4-(2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl)phenyl]acetamide; Acetamide, 2-chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-2-propyl)phenyl]-N-methyl-; CAS 294196-95-5
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-N-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-N-methylacetamide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and MS, is supplied with each shipment to guarantee traceability, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.