Description

4-(1-Amino-2,2,2-Trifluoro-Ethyl)-Phenol is a specialized fluorinated aromatic amine building block of significant interest in advanced organic synthesis. This compound matters for its unique trifluoroethylamine-phenol hybrid structure, which imparts valuable physicochemical properties to target molecules, such as enhanced metabolic stability and lipophilicity. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and pesticides with improved efficacy and environmental profiles.
• Liquid Crystal Materials: Serves as a precursor for fluorinated components in electronic display technologies.
• Advanced Polymer Chemistry: Incorporated as a monomer or cross-linking agent to create specialty polymers with unique thermal and chemical resistance.
• Organic Light-Emitting Diodes (OLEDs): Acts as a building block for electron-transport or host materials in optoelectronic devices.
• Chemical Research & Development: A versatile reagent for exploring new fluorination strategies and structure-activity relationships (SAR).

Basic Information

Product Name	4-(1-Amino-2,2,2-Trifluoro-Ethyl)-Phenol
CAS No.	294175-07-8
Molecular Formula	C8H8F3NO
Molecular Weight	191.15 g/mol
Synonyms	4-(1-Amino-2,2,2-trifluoroethyl)phenol; 4-(2,2,2-Trifluoro-1-aminoethyl)phenol; 1-(4-Hydroxyphenyl)-2,2,2-trifluoroethanamine; 2,2,2-Trifluoro-1-(4-hydroxyphenyl)ethanamine; α-(Aminomethyl)-4-hydroxybenzyl Alcohol, Trifluoro Derivative; 4-Hydroxy-α-(trifluoromethyl)benzylamine; TFAP
EINECS	Contact for details

Quality Control

Our 4-(1-Amino-2,2,2-Trifluoro-Ethyl)-Phenol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent batch-to-batch quality. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.